ZNF452

ZNF452 or Zinc Finger Protein 452 is a protein that in humans is encoded by the ZNF452 gene. The protein encoded by this gene is a zinc finger protein, a family of proteins characterized by the presence of one or more zinc finger domains. Zinc fingers are protein or peptide sequences in which a zinc ion is held in place by cysteine and/or histidine residues.

Function

ZNF452 is a member of the KRAB-ZFP subfamily, which is the largest subfamily of zinc finger proteins. The KRAB-ZFP subfamily is characterized by the presence of a Krüppel-associated box (KRAB) domain in addition to the zinc finger domains. The KRAB domain is a potent transcriptional repressor, and the zinc finger domains are responsible for binding to specific DNA sequences.

The exact function of ZNF452 is not well understood, but it is thought to play a role in gene regulation. Like other members of the KRAB-ZFP subfamily, it is likely involved in repressing the transcription of certain genes.

Clinical Significance

The role of ZNF452 in disease is not well understood. However, mutations in other members of the KRAB-ZFP subfamily have been associated with a variety of diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to determine whether ZNF452 plays a role in these or other diseases.

See Also

• Zinc finger
• Zinc finger protein
• KRAB-ZFP
• Gene regulation