ZNF649

ZNF649 or Zinc Finger Protein 649 is a protein that in humans is encoded by the ZNF649 gene. The protein encoded by this gene is a zinc finger protein and contains an N-terminal POZ domain. This protein acts as a sequence-specific transcription factor and has been shown to interact with, and inhibit the activity of, NF-kappa B (nuclear factor kappa-light-chain-enhancer of activated B cells) in the cell nucleus.

Function

ZNF649 is a transcriptional repressor that binds to the promoter region of target genes. This protein can inhibit the transcription of these genes by recruiting a histone deacetylase. This repression can be relieved by the binding of the activation domain of NF-kappa B.

Structure

The ZNF649 protein is a member of the POZ domain family of proteins. The POZ domain, also known as the BTB domain, is a protein-protein interaction domain that can form multimeric complexes. The ZNF649 protein also contains a Krüppel-type zinc finger domain, which allows it to bind to specific DNA sequences and regulate transcription.

Clinical Significance

While the exact role of ZNF649 in human disease is not fully understood, it is thought to play a role in the regulation of cell proliferation and apoptosis, which are processes that are often disrupted in cancer. Further research is needed to fully elucidate the role of this protein in human health and disease.

See Also

• Zinc finger
• POZ domain
• NF-kappa B
• Transcription factor
• Promoter (genetics)