Zoledronate

Zoledronate (also known as zoledronic acid) is a type of bisphosphonate medication used to treat a variety of bone diseases. These include osteoporosis, Paget's disease of bone, high blood calcium due to cancer, and bone complications due to cancer. It is given by injection into a vein.

Medical uses

Zoledronate is used to treat osteoporosis, Paget's disease of bone, high blood calcium due to cancer, and bone complications due to cancer. It is also used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer, as well as for treating osteoporosis.

Side effects

Common side effects include fever, joint pain, and feeling tired. Serious side effects may include osteonecrosis of the jaw, kidney problems, low blood calcium, and severe allergic reactions.

Mechanism of action

Zoledronate slows down the process of bone breakdown by inhibiting osteoclasts, the cells responsible for bone resorption. This helps to maintain a healthy balance between bone formation and breakdown, and reduces the risk of fractures.

History

Zoledronate was approved for medical use in the United States in 2001. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.

See also

• Bisphosphonate
• Osteoporosis
• Paget's disease of bone

Zoledronate Resources
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