Α-Chlorocodide

Α-Chlorocodide is a synthetic opioid analgesic drug, a derivative of codeine in which the 6-hydroxy group has been replaced by chlorine. Developed in the late 1950s, it has primarily been used in the treatment of moderate to severe pain.

Chemistry

Α-Chlorocodide is a chlorinated derivative of codeine that has similar pharmacological properties but with a more potent analgesic effect. It is synthesized by reacting codeine with Thionyl chloride, which substitutes a chlorine atom for the 6-hydroxy group.

Pharmacology

Like other opioids, Α-Chlorocodide acts on the mu-opioid receptors in the brain and spinal cord to relieve pain. It is more potent than codeine and has a similar side effect profile, including respiratory depression, constipation, and dependence.

Clinical Use

Α-Chlorocodide has been used in the treatment of moderate to severe pain, including post-operative pain, cancer pain, and chronic pain conditions. It is usually administered orally, but can also be given by intramuscular injection.

Side Effects

The side effects of Α-Chlorocodide are similar to those of other opioids and include drowsiness, dizziness, nausea, vomiting, constipation, and respiratory depression. Long-term use can lead to physical dependence and withdrawal symptoms if the drug is discontinued abruptly.

See Also

• Opioid
• Codeine
• Mu-opioid receptor
• Thionyl chloride