17-Hydroxyprogesterone acetate

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17-Hydroxyprogesterone acetate (17-OHPA) is a progestogen that is derived from progesterone. It is a synthetic steroid hormone that is used in the formulation of certain medications. As a progestogen, it has various effects on the endocrine system, particularly in the regulation of the menstrual cycle and pregnancy. This compound is closely related to other progestogens such as 17-alpha-hydroxyprogesterone caproate (17-OHPC), which is used to prevent preterm birth in pregnant women with a history of delivering prematurely.

Chemical Structure and Function[edit | edit source]

17-Hydroxyprogesterone acetate is a derivative of 17-hydroxyprogesterone, which is a naturally occurring metabolite of progesterone. The addition of an acetate group to 17-hydroxyprogesterone increases its progestogenic activity, making it more effective as a medication. This modification also affects its pharmacokinetics, including its absorption, distribution, metabolism, and excretion (ADME) profile.

Medical Uses[edit | edit source]

17-OHPA is used in various therapeutic contexts. Its primary application is in the field of gynecology, where it is used to treat conditions related to progesterone deficiency. These conditions may include:

Pharmacology[edit | edit source]

The pharmacological action of 17-OHPA is primarily through its interaction with progesterone receptors in the body, mimicking the effects of natural progesterone. This interaction influences various physiological processes, including the menstrual cycle and the maintenance of pregnancy.

Side Effects[edit | edit source]

Like all medications, 17-OHPA can cause side effects. These may vary from mild to severe and can include symptoms such as nausea, bloating, headache, and changes in mood or libido. More serious side effects may also occur, and patients are advised to consult their healthcare provider if they experience any adverse effects while taking this medication.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD