17-hydroxyprogesterone
Overview of 17-hydroxyprogesterone
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| PubChem | 9271 |
| ChemSpider | 8910 |
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17-Hydroxyprogesterone (17-OHP) is a naturally occurring steroid hormone involved in the biosynthesis of glucocorticoids and sex steroids. It is a C21 steroid and a derivative of progesterone.
Biochemistry[edit | edit source]
17-Hydroxyprogesterone is produced in the adrenal glands, gonads, and placenta as part of the steroidogenesis pathway. It is synthesized from progesterone by the enzyme 17α-hydroxylase (CYP17A1). 17-OHP serves as a precursor to cortisol and androstenedione, which can be further converted into testosterone and estradiol.
Clinical Significance[edit | edit source]
17-Hydroxyprogesterone is clinically significant as a marker for congenital adrenal hyperplasia (CAH), a group of genetic disorders affecting adrenal steroid synthesis. The most common form of CAH is due to 21-hydroxylase deficiency, leading to elevated levels of 17-OHP. Measurement of 17-OHP levels is used in newborn screening programs to detect CAH.
Testing and Diagnosis[edit | edit source]
The measurement of 17-OHP is typically performed using immunoassay techniques or mass spectrometry. Elevated levels of 17-OHP in the blood can indicate CAH, particularly in newborns. In adults, abnormal levels may suggest adrenal tumors or other endocrine disorders.
Therapeutic Use[edit | edit source]
17-Hydroxyprogesterone caproate is a synthetic derivative used in the prevention of preterm birth in women with a history of spontaneous preterm delivery. It is administered as an intramuscular injection.
Also see[edit | edit source]
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