18-Hydroxy-11-deoxycorticosterone

18-Hydroxy-11-deoxycorticosterone (18-OH-DOC) is a steroid that is produced in the adrenal gland. It is a precursor to aldosterone, a hormone that helps regulate the balance of sodium and potassium in the body.

Structure and Synthesis

18-Hydroxy-11-deoxycorticosterone is a steroid, a type of organic compound that is characterized by a specific arrangement of carbon atoms in a four-ring structure. It is synthesized in the adrenal gland from progesterone through a series of enzymatic reactions. The final step in the synthesis of 18-OH-DOC is the hydroxylation of 11-deoxycorticosterone by the enzyme CYP11B2.

Function

18-OH-DOC is a precursor to aldosterone, a hormone that plays a crucial role in maintaining the body's balance of sodium and potassium. This balance is important for a number of physiological processes, including the regulation of blood pressure and fluid balance. By converting to aldosterone, 18-OH-DOC contributes to these processes.

Clinical Significance

Abnormal levels of 18-OH-DOC can be indicative of certain medical conditions. For example, elevated levels of 18-OH-DOC can be a sign of congenital adrenal hyperplasia, a group of genetic disorders that affect the adrenal glands. Conversely, low levels of 18-OH-DOC can indicate adrenal insufficiency, a condition in which the adrenal glands do not produce enough steroid hormones.

See Also

• Steroid
• Aldosterone
• Congenital adrenal hyperplasia
• Adrenal insufficiency