18-Hydroxy-11-deoxycorticosterone
18-Hydroxy-11-deoxycorticosterone
18-Hydroxy-11-deoxycorticosterone is a steroid hormone that plays a role in the aldosterone biosynthesis pathway. It is a precursor to aldosterone, a hormone critical for sodium retention, potassium excretion, and blood pressure regulation.
Biosynthesis[edit | edit source]
18-Hydroxy-11-deoxycorticosterone is synthesized in the adrenal cortex, specifically in the zona glomerulosa. It is derived from 11-deoxycorticosterone through the action of the enzyme aldosterone synthase (CYP11B2). This enzyme catalyzes the hydroxylation at the 18th carbon position, converting 11-deoxycorticosterone into 18-hydroxy-11-deoxycorticosterone.
Function[edit | edit source]
The primary function of 18-hydroxy-11-deoxycorticosterone is as an intermediate in the production of aldosterone. Aldosterone is essential for maintaining electrolyte balance and blood pressure homeostasis. It acts on the kidneys to promote sodium reabsorption and potassium excretion, which in turn influences water retention and blood volume.
Clinical Significance[edit | edit source]
Abnormal levels of 18-hydroxy-11-deoxycorticosterone can be indicative of disorders in aldosterone synthesis. Elevated levels may be associated with conditions such as primary aldosteronism, where there is excessive production of aldosterone, leading to hypertension and hypokalemia.
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