From WikiMD's Food, Medicine & Wellness Encyclopedia

18-Methyltestosterone is a synthetic, orally active androgen and anabolic steroid (AAS) which is used primarily in the treatment of low testosterone levels in men. It is also used in women to treat breast cancer, postpartum breast pain and engorgement, and menopause symptoms. 18-Methyltestosterone is a derivative of testosterone, differing only by the addition of a methyl group at the C18 position, which significantly alters its hormonal activity.

Medical Uses[edit | edit source]

18-Methyltestosterone is indicated for the replacement therapy in conditions associated with a deficiency or absence of endogenous testosterone in males. In females, it has been prescribed for the treatment of advanced inoperable breast cancer. It is important to note that the use of 18-Methyltestosterone in performance enhancement is not approved by medical guidelines and is considered doping in sports.

Pharmacology[edit | edit source]

Mechanism of Action[edit | edit source]

As an androgen, 18-Methyltestosterone binds to and activates specific nuclear receptors, leading to an increase in protein synthesis, muscle mass, and strength, as well as a decrease in fat mass. It also has some degree of estrogenic activity due to its ability to act as a substrate for aromatase, the enzyme that converts androgens to estrogens.

Pharmacokinetics[edit | edit source]

Orally administered, 18-Methyltestosterone is absorbed through the gastrointestinal tract, with a bioavailability significantly enhanced by the methyl group at the C18 position. This modification allows it to resist metabolism by the liver, increasing its half-life and making it effective for oral administration.

Adverse Effects[edit | edit source]

The use of 18-Methyltestosterone can lead to a range of adverse effects, particularly when used at high doses or for prolonged periods. These can include liver toxicity, changes in cholesterol levels, increased risk of cardiovascular disease, masculinization in women, and suppression of natural testosterone production in men. It is crucial for users to monitor their health through regular medical supervision.

Legal Status[edit | edit source]

The legal status of 18-Methyltestosterone varies by country. In some jurisdictions, it is a controlled substance, meaning its use and distribution are restricted to medical applications and it cannot be legally obtained without a prescription.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD