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2,2-Dimethoxypropane is an organic compound with the molecular formula C5H12O2. This compound is commonly used as a dehydration reagent and a protecting group for hydroxyl groups in organic synthesis.

Structure and Properties[edit | edit source]

2,2-Dimethoxypropane is a clear, colorless liquid that is slightly soluble in water. It has a sweet, ether-like odor. The compound has a molecular weight of 104.15 g/mol and a density of 0.868 g/mL at 25 °C. It has a boiling point of 83 °C and a melting point of -60 °C.

Synthesis[edit | edit source]

2,2-Dimethoxyproane can be synthesized by the reaction of acetone with methanol in the presence of an acid catalyst. The reaction proceeds via the formation of a hemiacetal, followed by dehydration to give the final product.

Uses[edit | edit source]

In organic synthesis, 2,2-dimethoxypropane is used as a protecting group for hydroxyl groups. It is also used as a dehydration reagent, particularly for the preparation of samples for gas chromatography.

Safety[edit | edit source]

2,2-Dimethoxypropane is flammable and should be handled with care. It can cause irritation to the eyes, skin, and respiratory tract.

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD