2,4-diacetylphloroglucinol

2,4-Diacetylphloroglucinol (2,4-DAPG) is a polyketide molecule with antibiotic properties. It is produced by several strains of Pseudomonas bacteria, particularly Pseudomonas fluorescens, and plays a crucial role in their ability to suppress plant diseases.

Structure and Synthesis

2,4-DAPG has a unique structure, consisting of a benzene ring with two acetyl groups and a hydroxyl group attached. The molecule is synthesized by a complex process involving several enzymes, including a type III polyketide synthase.

Biological Activity

2,4-DAPG has broad-spectrum antibiotic activity against a variety of pathogens, including bacteria, fungi, and nematodes. It is particularly effective against certain plant pathogens, such as Gaeumannomyces graminis var. tritici, the causative agent of take-all disease in wheat.

Role in Disease Suppression

The ability of Pseudomonas fluorescens to suppress plant diseases is largely due to its production of 2,4-DAPG. The molecule inhibits the growth of pathogens in the root zone of the plant, thereby preventing disease development. This has led to the use of P. fluorescens strains as biocontrol agents in agriculture.

Potential Medical Applications

Research is ongoing into the potential use of 2,4-DAPG in human medicine. Its broad-spectrum antibiotic activity could make it a valuable tool in the fight against multi-drug resistant pathogens.

See Also

• Pseudomonas fluorescens
• Polyketide
• Biocontrol

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