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2,5-Dimethoxy-4-methylamphetamine (DOM), also known as STP (Serenity, Tranquility, and Peace), is a psychedelic drug and a member of the amphetamine family. It was first synthesized and documented in 1963 by Alexander Shulgin, a renowned American medicinal chemist and psychopharmacologist.

Chemistry[edit | edit source]

2,5-Dimethoxy-4-methylamphetamine is a synthetic compound of the phenethylamine class. The chemical structure consists of a phenethylamine core, an alkyl substituent at the alpha carbon, and two methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. It also has a methyl group CH3- attached to carbon R4 of the benzene ring.

Pharmacology[edit | edit source]

The pharmacological action of 2,5-Dimethoxy-4-methylamphetamine is primarily through its agonist activity at the 5-HT2A receptor. The drug is also a potent partial agonist at the 5-HT2C receptor. These receptors are a subtype of the serotonin receptors and are known to be involved in the cognitive and perceptual effects of psychedelics.

Effects[edit | edit source]

The effects of 2,5-Dimethoxy-4-methylamphetamine can vary greatly, depending on the dose and individual's physiology. At lower doses, the effects may include enhanced mood, increased energy, and heightened sensory perception. At higher doses, the effects can be more intense and may include hallucinations, altered perception of time and space, and profound changes in thought and mood.

History and usage[edit | edit source]

2,5-Dimethoxy-4-methylamphetamine was first synthesized by Alexander Shulgin in 1963. In the late 1960s, it was distributed under the name "STP" and was used as a recreational drug. However, due to its long duration of action and unpredictable effects, it quickly fell out of favor.

Legal status[edit | edit source]

In many countries, including the United States, 2,5-Dimethoxy-4-methylamphetamine is classified as a Schedule I drug under the Controlled Substances Act, meaning it has a high potential for abuse and no accepted medical use.

See also[edit | edit source]

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Contributors: Prab R. Tumpati, MD