From WikiMD's Food, Medicine & Wellness Encyclopedia

2,6-Dihydroxypyridine is an organic compound that is a derivative of pyridine. It is a white solid that is soluble in water and polar organic solvents. It is used as a precursor to other compounds due to its ability to act as a ligand.

Structure and Properties[edit | edit source]

2,6-Dihydroxypyridine is a heterocyclic compound with the formula C5H5NO2. It consists of a six-membered ring with two hydroxyl groups attached to the 2 and 6 positions, and a nitrogen atom at the 1 position. The molecule is planar due to the sp2 hybridization of the carbon and nitrogen atoms.

The presence of the hydroxyl groups and the nitrogen atom gives 2,6-dihydroxypyridine the ability to form hydrogen bonds, which contributes to its solubility in water and polar organic solvents. The nitrogen atom also allows it to act as a ligand, forming coordination complexes with various metal ions.

Synthesis[edit | edit source]

2,6-Dihydroxypyridine can be synthesized from pyridine through a two-step process. First, pyridine is oxidized to pyridine N-oxide using an oxidizing agent such as hydrogen peroxide. Then, the pyridine N-oxide is treated with a base to remove the oxide group, resulting in the formation of 2,6-dihydroxypyridine.

Applications[edit | edit source]

2,6-Dihydroxypyridine is primarily used as a precursor to other compounds. For example, it can be used to synthesize pyridine dicarboxylic acid, a compound that is used in the production of polyesters and resins. It can also be used to synthesize bipyridine, a compound that is used as a ligand in many coordination complexes.

Safety[edit | edit source]

As with many organic compounds, 2,6-dihydroxypyridine should be handled with care. It can cause irritation to the skin and eyes, and ingestion or inhalation can lead to harmful effects. Proper personal protective equipment should be worn when handling this compound.


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Contributors: Prab R. Tumpati, MD