From WikiMD's Food, Medicine & Wellness Encyclopedia

2-Aminotetralin (2-AT), also known as 2-Amino-1,2,3,4-tetrahydronaphthalene, is a compound that has been found to act as an agonist of the serotonin 5-HT1A receptor and 5-HT7 receptor. It is structurally related to the serotonergic psychedelic 2C-B.

Chemistry[edit | edit source]

2-AT is a tetralin that is structurally related to the psychedelic 2C-B and other phenethylamines. It is a chiral compound with two stereocenters, meaning it has four possible stereoisomers.

Pharmacology[edit | edit source]

2-AT has been found to act as an agonist of the serotonin 5-HT1A receptor and 5-HT7 receptor. The 5-HT1A receptor is a subtype of the 5-HT receptor that binds the neurotransmitter serotonin, and is thought to be responsible for the regulation of mood, anxiety, appetite, and sleep. The 5-HT7 receptor is also a serotonin receptor subtype, and is thought to be involved in the regulation of mood, circadian rhythm, and thermoregulation.

Research[edit | edit source]

Research on 2-AT has primarily focused on its potential use in the treatment of depression and anxiety disorders. It has been found to have antidepressant and anxiolytic effects in animal models, and is thought to exert these effects through its action on the 5-HT1A and 5-HT7 receptors.

See also[edit | edit source]

2-AT Resources
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Contributors: Prab R. Tumpati, MD