2-Oxoquazepam
Chemical compound
| 2-Oxoquazepam | |
|---|---|
| [[File:|frameless|220px|alt=|]] | |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
2-Oxoquazepam is a benzodiazepine derivative. It is a minor metabolite of the drug quazepam, which is used primarily for the treatment of insomnia.
Pharmacology[edit | edit source]
2-Oxoquazepam acts on the central nervous system by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor. This action results in sedative, hypnotic, and anxiolytic effects, which are characteristic of benzodiazepines.
Metabolism[edit | edit source]
2-Oxoquazepam is formed in the body as a metabolite of quazepam. Quazepam is metabolized in the liver by the cytochrome P450 enzyme system, particularly by the CYP3A4 and CYP2C19 isoenzymes. The primary metabolites of quazepam are 2-oxoquazepam and N-desalkyl-2-oxoquazepam.
Clinical Use[edit | edit source]
While 2-oxoquazepam itself is not marketed as a drug, its parent compound, quazepam, is used in the treatment of insomnia. Quazepam is known for its relatively long half-life and its ability to maintain sleep without significant residual effects the next day.
Side Effects[edit | edit source]
The side effects of 2-oxoquazepam are similar to those of other benzodiazepines and may include drowsiness, dizziness, fatigue, and cognitive impairment. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.
Legal Status[edit | edit source]
The legal status of 2-oxoquazepam is not well-defined, as it is not marketed as a standalone drug. However, its parent compound, quazepam, is classified as a Schedule IV controlled substance under the Controlled Substances Act in the United States, indicating a potential for abuse and dependence.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
