20-Hydroxy-LTB4

20-Hydroxy-LTB4 is a biologically active metabolite of leukotriene B4 (LTB4), which is a potent inflammatory mediator involved in various physiological and pathological processes. This compound is part of the eicosanoid family, which are signaling molecules derived from arachidonic acid.

Biochemical Pathway

20-Hydroxy-LTB4 is formed through the enzymatic oxidation of LTB4 by cytochrome P450 enzymes, specifically those in the CYP4F subfamily. This conversion is part of the metabolic inactivation pathway of LTB4, which serves to regulate its biological activity and limit its pro-inflammatory effects.

Biological Function

20-Hydroxy-LTB4 retains some of the biological activities of its precursor, LTB4, but with reduced potency. It acts on the same G protein-coupled receptors (GPCRs) as LTB4, namely BLT1 and BLT2 receptors, but with lower affinity. This metabolite is involved in modulating immune responses, particularly in the context of inflammation and leukocyte chemotaxis.

Clinical Significance

The regulation of LTB4 and its metabolites, including 20-Hydroxy-LTB4, is of clinical interest due to their roles in inflammatory diseases such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Understanding the balance between LTB4 and its metabolites can provide insights into the development of therapeutic strategies aimed at modulating inflammatory responses.

Research and Development

Research into 20-Hydroxy-LTB4 focuses on its role in inflammation and its potential as a biomarker for disease activity. Studies are also exploring the therapeutic potential of targeting the enzymes involved in its synthesis and degradation to develop new anti-inflammatory drugs.

Also see

• Leukotriene B4
• Eicosanoids
• Cytochrome P450
• Inflammation
• BLT1 receptor
• BLT2 receptor