Prostanoid

Prostanoids are a subclass of eicosanoids, which are lipid compounds derived from fatty acids. They are produced by almost all mammals and have a wide range of biological functions. Prostanoids are produced by the enzyme cyclooxygenase (COX) and include prostaglandins, thromboxanes, and prostacyclins.

Production

Prostanoids are produced from arachidonic acid by the action of the enzyme cyclooxygenase. There are two types of COX enzymes, COX-1 and COX-2, which have different functions in the body. COX-1 is involved in the production of prostanoids that regulate normal physiological processes, while COX-2 is involved in the production of prostanoids that mediate inflammation and pain.

Types

There are three main types of prostanoids: prostaglandins, thromboxanes, and prostacyclins.

Prostaglandins

Prostaglandins are a group of prostanoids that have a wide range of biological functions. They are involved in the regulation of inflammation, pain, fever, and the immune system. Prostaglandins also play a role in the regulation of blood pressure, gastrointestinal integrity, and kidney function.

Thromboxanes

Thromboxanes are a group of prostanoids that are involved in the regulation of blood clotting and vascular tone. They are produced by platelets and have a role in the promotion of platelet aggregation and vasoconstriction.

Prostacyclins

Prostacyclins are a group of prostanoids that have a role in the regulation of vasodilation and inhibition of platelet aggregation. They are produced by the endothelial cells of the blood vessels.

Clinical significance

Prostanoids have a wide range of clinical significance. They are involved in various pathological conditions such as inflammation, pain, cardiovascular diseases, and cancer. Drugs that inhibit the production of prostanoids, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are commonly used in the treatment of these conditions.

See also

• Eicosanoid
• Cyclooxygenase
• Prostaglandin
• Thromboxane
• Prostacyclin

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