20-Hydroxyecdysone

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A naturally occurring ecdysteroid hormone



20-Hydroxyecdysone is a naturally occurring ecdysteroid hormone found in arthropods and some plants. It plays a crucial role in the molting and metamorphosis of insects and is also involved in various physiological processes in other organisms.

Structure[edit | edit source]

20-Hydroxyecdysone is a steroid hormone with a complex structure characterized by multiple hydroxyl groups. Its chemical formula is C27H44O7. The molecule consists of a cholestane backbone with hydroxyl groups at specific positions, which are critical for its biological activity.

Chemical structure of 20-Hydroxyecdysone
3D ball-and-stick model of 20-Hydroxyecdysone

Biological Role[edit | edit source]

In insects, 20-Hydroxyecdysone is a key hormone that regulates ecdysis, the process of shedding the old exoskeleton during growth and development. It is synthesized from cholesterol and acts by binding to the ecdysone receptor, a type of nuclear receptor. This binding initiates a cascade of gene expression changes that lead to molting and metamorphosis.

Sources[edit | edit source]

20-Hydroxyecdysone is not only found in insects but also in certain plants, where it may serve as a defense mechanism against herbivores. Some plants, such as spinach and quinoa, contain significant amounts of this hormone, which can have effects on vertebrates when ingested.

Applications[edit | edit source]

Due to its anabolic properties, 20-Hydroxyecdysone has been studied for potential applications in medicine and sports nutrition. It is believed to enhance protein synthesis and muscle growth, although its effects in humans are still under investigation.

Related pages[edit | edit source]

Gallery[edit | edit source]

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Contributors: Prab R. Tumpati, MD