25I-NB34MD

25I-NB34MD (also known as 2C-I-NBOMe-3,4-dimethyl) is a psychedelic drug and derivative of the phenethylamine psychedelic 2C-I. It was discovered in 2011 by a team at Purdue University led by David Nichols. The drug is part of the NBOMe series of psychedelics, which are known for their high potency and selectivity for the 5-HT2A receptor.

Chemistry

25I-NB34MD is a derivative of 2C-I, which itself is a member of the 2C family of psychedelics. The chemical structure of 25I-NB34MD includes a methoxy group at the 2 and 5 positions of the phenyl ring, and a nitro group at the 4 position. The 3 and 4 positions of the phenyl ring are substituted with methyl groups. The nitrogen of the ethylamine chain is substituted with a 2-methoxybenzyl (BOMe) group.

Pharmacology

The exact mechanism of action of 25I-NB34MD is not fully understood. However, it is known to act as a highly potent partial agonist for the 5-HT2A receptor. The drug's effects are believed to result from its activity at this receptor, which is primarily found in the prefrontal cortex of the human brain. This area of the brain is involved in functions such as cognition, memory, and mood.

Effects

The effects of 25I-NB34MD can vary greatly depending on the dose, set, and setting. Common effects reported by users include visual hallucinations, enhanced colors, increased appreciation for music, euphoria, and altered thought patterns. Some users also report experiencing negative effects such as anxiety, paranoia, and uncomfortable body sensations.

Legal Status

The legal status of 25I-NB34MD varies by country. In many countries, including the United States, it is classified as a Schedule I drug, making it illegal to manufacture, distribute, or possess.

Safety

As with all psychedelics, the use of 25I-NB34MD carries risks. These include psychological risks, such as the potential for triggering latent mental health issues, and physical risks, such as the potential for overdose. Due to the drug's high potency and the lack of research on its long-term effects, it is generally advised to use caution when taking 25I-NB34MD.

See Also

• 25I-NBOMe
• 2C-I
• Psychedelic drug
• David Nichols