3,4-Difluoroamphetamine

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3,4-Difluoroamphetamine (3,4-DFA) is a psychoactive drug and a fluorinated amphetamine derivative. It acts as a releasing agent that produces stimulant effects.

Chemistry[edit | edit source]

3,4-DFA is a substituted amphetamine, which refers to a broad category of compounds containing a phenethylamine core with an alkyl group attached to the alpha carbon, and a methyl group attached to the amine. In the case of 3,4-DFA, the alpha carbon is substituted with a fluorine atom.

Pharmacology[edit | edit source]

The pharmacodynamics of 3,4-DFA are not fully understood. However, it is known to act as a releasing agent and reuptake inhibitor for the monoamine neurotransmitters dopamine, norepinephrine, and serotonin. This leads to an increase in the synaptic concentration of these neurotransmitters, which can result in stimulant effects.

Effects[edit | edit source]

The effects of 3,4-DFA can vary greatly depending on the dose and individual's physiology. Common effects can include stimulation, euphoria, increased alertness, and increased sociability. However, higher doses can lead to negative effects such as anxiety, paranoia, and psychosis.

Toxicity[edit | edit source]

The toxicity of 3,4-DFA is not fully known due to the lack of human and animal studies. However, it is thought to have a similar toxicity profile to other amphetamine derivatives.

Legal Status[edit | edit source]

The legal status of 3,4-DFA varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD