3-APB

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Chemical compound


3-APB
Chemical structure of 3-APB
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
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Legal status
CAS Number 286834-80-8
PubChem 44469364
DrugBank
ChemSpider 23272992
KEGG


3-APB (1-(1-benzofuran-3-yl)propan-2-amine) is a chemical compound that acts as a psychoactive drug. It is structurally related to the phenethylamine class of compounds and is known for its effects on the central nervous system.

Chemical Structure and Properties[edit | edit source]

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Chemical structure of 3-APB

3-APB is a derivative of benzofuran, a bicyclic compound consisting of a benzene ring fused to a furan ring. The compound has a molecular formula of C11H13NO and a molecular weight of 175.23 g/mol. The presence of the amine group in its structure classifies it as an amine, specifically a secondary amine due to the attachment of the amine group to a secondary carbon.

Pharmacology[edit | edit source]

3-APB is known to interact with the serotonin and dopamine systems in the brain, which are neurotransmitter systems involved in mood regulation, reward, and cognition. The compound is believed to act as a serotonin receptor agonist, which may contribute to its psychoactive effects. Additionally, 3-APB may have affinity for the dopamine receptors, although its exact mechanism of action is not fully understood.

Effects[edit | edit source]

The effects of 3-APB are similar to those of other entactogens, a class of psychoactive drugs that promote feelings of emotional closeness and empathy. Users have reported experiencing enhanced mood, increased sociability, and heightened sensory perception. However, the use of 3-APB can also lead to adverse effects such as anxiety, paranoia, and tachycardia.

Legal Status[edit | edit source]

The legal status of 3-APB varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In others, it may be available for research purposes under specific regulations.

Synthesis[edit | edit source]

The synthesis of 3-APB involves the reaction of benzofuran with appropriate reagents to introduce the amine group at the 3-position of the benzofuran ring. This process typically requires the use of specialized chemical techniques and equipment, and is conducted in a laboratory setting.

Safety and Toxicity[edit | edit source]

The safety profile of 3-APB is not well-established, and its use is associated with potential health risks. As with other psychoactive substances, the risk of overdose and adverse reactions is a concern. Users are advised to exercise caution and to be aware of the legal implications of possessing and using 3-APB.

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Contributors: Prab R. Tumpati, MD