3-Hydroxymorphinan
3-Hydroxymorphinan is an active metabolite of the opioid analgesic drug dextromethorphan. It is formed in the body after the administration of dextromethorphan and is responsible for some of the drug's analgesic effects.
Pharmacology[edit | edit source]
3-Hydroxymorphinan acts as an antagonist at the NMDA receptor, which is a type of glutamate receptor that plays a key role in learning and memory. By blocking this receptor, 3-Hydroxymorphinan can reduce the perception of pain.
In addition to its NMDA receptor antagonism, 3-Hydroxymorphinan also has affinity for the sigma-1 receptor, which is involved in the regulation of neurotransmitter release. This may contribute to its analgesic effects.
Clinical Use[edit | edit source]
3-Hydroxymorphinan is not used clinically on its own, but is formed in the body after the administration of dextromethorphan. Dextromethorphan is used as a cough suppressant and also has analgesic properties. The formation of 3-Hydroxymorphinan contributes to these analgesic effects.
Side Effects[edit | edit source]
As a metabolite of dextromethorphan, 3-Hydroxymorphinan can contribute to the side effects of this drug. These can include nausea, vomiting, dizziness, and sedation. In rare cases, high doses of dextromethorphan can lead to a serious condition called serotonin syndrome, which is characterized by agitation, hallucinations, rapid heartbeat, and high body temperature.
See Also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
