4-Androstene-3,6,17-trione

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4-Androstene-3,6,17-trione

Chemical structure of 4-Androstene-3,6,17-trione

4-Androstene-3,6,17-trione is a steroidal aromatase inhibitor. It is a compound that is used in the field of endocrinology and sports medicine for its ability to inhibit the enzyme aromatase, which is responsible for the conversion of androgens into estrogens.

Chemical Structure[edit | edit source]

4-Androstene-3,6,17-trione is a derivative of androstane, a steroid nucleus. The compound is characterized by the presence of three keto groups at the 3, 6, and 17 positions of the androstene structure. This configuration is crucial for its biological activity as an aromatase inhibitor.

Mechanism of Action[edit | edit source]

As an aromatase inhibitor, 4-Androstene-3,6,17-trione works by binding to the aromatase enzyme, thereby preventing it from converting testosterone and other androgens into estrogen. This reduction in estrogen levels can be beneficial in conditions where estrogen plays a role in disease progression, such as certain types of breast cancer.

Uses in Medicine[edit | edit source]

4-Androstene-3,6,17-trione has been studied for its potential use in the treatment of estrogen-dependent conditions. It is of particular interest in the management of gynecomastia and as an adjunct in hormone therapy for breast cancer. However, its use is not as widespread as other aromatase inhibitors like anastrozole or letrozole.

Use in Sports[edit | edit source]

In the realm of sports medicine, 4-Androstene-3,6,17-trione is sometimes used by athletes and bodybuilders to reduce estrogen levels, which can help in maintaining a leaner physique and preventing estrogen-related side effects of anabolic steroid use, such as water retention and gynecomastia.

Safety and Side Effects[edit | edit source]

The use of 4-Androstene-3,6,17-trione, like other aromatase inhibitors, can lead to a decrease in bone mineral density due to lower estrogen levels, potentially increasing the risk of osteoporosis. Other side effects may include joint pain, hot flashes, and fatigue.

Legal Status[edit | edit source]

The legal status of 4-Androstene-3,6,17-trione varies by country. In some regions, it is classified as a controlled substance due to its potential for misuse in sports.

Related Pages[edit | edit source]

4-Androstene-3,6,17-trione[edit | edit source]

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Contributors: Prab R. Tumpati, MD