4-Hydroxyestrone

4-Hydroxyestrone is a type of estrogen metabolite that is formed in the body through the process of hydroxylation. It is one of the three main types of estrogen metabolites, the other two being 2-Hydroxyestrone and 16α-Hydroxyestrone. These metabolites are formed in the liver and have different effects on the body.

Metabolism

4-Hydroxyestrone is formed in the body through the process of hydroxylation, which is a type of oxidation reaction. This process is catalyzed by the enzyme cytochrome P450, specifically the CYP1B1 isoform. The formation of 4-Hydroxyestrone is part of the body's natural metabolism of estrogen.

Effects

4-Hydroxyestrone is considered to be a potent estrogen, meaning that it has a strong effect on the body. It has been found to stimulate the growth of breast cancer cells in laboratory studies, suggesting that it may play a role in the development of this disease. However, more research is needed to fully understand the effects of this metabolite on the body.

See also

• Estrogen
• Estrogen receptor
• Estrogen metabolism
• Breast cancer

References

4-Hydroxyestrone Resources
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