16α-Hydroxyestrone
16α-Hydroxyestrone (16α-OH-E1) is a metabolite of the estrogen estrone. It is formed through the hydroxylation of estrone at the C16α position. This compound is one of the many estrogen metabolites that can be found in the human body.
Biological Role[edit | edit source]
16α-Hydroxyestrone is known to exhibit estrogenic activity, although its potency is generally lower than that of estradiol. It is involved in various physiological processes and has been studied for its potential role in breast cancer and other hormone-related cancers. Elevated levels of 16α-Hydroxyestrone have been associated with an increased risk of developing certain types of cancer.
Metabolism[edit | edit source]
The metabolism of 16α-Hydroxyestrone involves its formation from estrone via the action of specific cytochrome P450 enzymes. It can be further metabolized into other compounds, including estriol and 16α-hydroxyestradiol.
Clinical Significance[edit | edit source]
The measurement of 16α-Hydroxyestrone levels can be used as a biomarker for assessing the risk of hormone-related cancers. It is also of interest in the study of endocrine disorders and the effects of hormone replacement therapy.
See Also[edit | edit source]
References[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
