5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid
5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid is a chemical compound belonging to the class of barbiturates. Barbiturates are derivatives of barbituric acid and act as central nervous system depressants. This particular compound is a synthetic derivative with specific structural modifications that influence its pharmacological properties.
Chemical Structure and Properties[edit | edit source]
5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid is characterized by the presence of an ethyl group and a 1,3-dimethylbut-1'-enyl group attached to the barbituric acid core. The chemical formula is C12H18N2O3, and it has a molecular weight of 238.29 g/mol.
Synthesis[edit | edit source]
The synthesis of 5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid involves the alkylation of barbituric acid with appropriate alkyl halides under controlled conditions. The reaction typically requires a base to deprotonate the barbituric acid, facilitating the nucleophilic attack on the alkyl halide.
Physical Properties[edit | edit source]
This compound is typically a crystalline solid at room temperature. It is sparingly soluble in water but more soluble in organic solvents such as ethanol and chloroform.
Pharmacology[edit | edit source]
Barbiturates, including 5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid, act by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor. This results in increased inhibitory effects in the central nervous system, leading to sedation, hypnosis, and in higher doses, anesthesia.
Clinical Use[edit | edit source]
While barbiturates were once widely used for their sedative and hypnotic properties, their use has declined due to the development of safer alternatives such as benzodiazepines. However, certain barbiturates are still used in specific clinical settings, such as in the treatment of epilepsy and for inducing anesthesia.
Side Effects and Risks[edit | edit source]
Barbiturates can cause a range of side effects, including drowsiness, dizziness, and respiratory depression. They have a narrow therapeutic index, meaning the difference between a therapeutic dose and a toxic dose is small. Overdose can lead to severe respiratory depression and death.
Regulation and Legal Status[edit | edit source]
Due to their potential for abuse and dependence, barbiturates are classified as controlled substances in many countries. The specific legal status of 5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid may vary depending on local regulations.
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
