5-HT7
5-HT7 receptor is a type of 5-HT receptor that binds the neurotransmitter serotonin. It is involved in a variety of functions, including circadian rhythm, learning, and memory.
Structure[edit | edit source]
The 5-HT7 receptor is a G protein-coupled receptor (GPCR) that is composed of seven transmembrane domains. It is coupled to the G protein Gs, which activates adenylyl cyclase and increases levels of cAMP in the cell.
Function[edit | edit source]
The 5-HT7 receptor is involved in a variety of physiological and neurological processes. It plays a role in the regulation of circadian rhythms, thermoregulation, and mood. It is also involved in the modulation of learning and memory processes.
Clinical significance[edit | edit source]
Alterations in the function or expression of the 5-HT7 receptor have been implicated in a variety of psychiatric disorders, including depression, anxiety, and schizophrenia. Several antipsychotic and antidepressant drugs have been found to act, at least in part, through the 5-HT7 receptor.
See also[edit | edit source]
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