5-HT7

5-HT7 receptor is a type of 5-HT receptor that binds the neurotransmitter serotonin. It is involved in a variety of functions, including circadian rhythm, learning, and memory.

Structure

The 5-HT7 receptor is a G protein-coupled receptor (GPCR) that is composed of seven transmembrane domains. It is coupled to the G protein Gs, which activates adenylyl cyclase and increases levels of cAMP in the cell.

Function

The 5-HT7 receptor is involved in a variety of physiological and neurological processes. It plays a role in the regulation of circadian rhythms, thermoregulation, and mood. It is also involved in the modulation of learning and memory processes.

Clinical significance

Alterations in the function or expression of the 5-HT7 receptor have been implicated in a variety of psychiatric disorders, including depression, anxiety, and schizophrenia. Several antipsychotic and antidepressant drugs have been found to act, at least in part, through the 5-HT7 receptor.

See also

• 5-HT receptor
• Serotonin
• Neurotransmitter
• G protein-coupled receptor

5-HT7 Resources
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