5F-MDMB-PICA

5F-MDMB-PICA

Synthetic cannabinoid

{{Drugbox | verifiedrevid = 477318464 | IUPAC_name = Methyl 2-[[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino]-3,3-dimethylbutanoate | image = 5F-MDMB-PICA_structure.png | width = 200 | legal_uk = Class B | legal_us = Schedule I | legal_ca = Schedule II | legal_de = Anlage II | CAS_number = 1971007-92-7 | PubChem = 119025022 | ChemSpiderID = 52085000 | UNII = 7J1X0F7F3V | C=20 | H=28 | F=1 | N=3 | O=3 | smiles = CC(C)(C)C(C(=O)OC)NC(=O)c1cn(CCCCC(F)F)c2c1cccc2 | StdInChI = 1S/C20H28FN3O3/c1-20(2,3)17(19(26)27-4)23-18(25)16-14-12-10-9-11-13(14)15(22-16)7-5-6-8-21/h9-12,17H,5-8H2,1-4H3,(H,22,23,25) | StdInChIKey = QWZQXKZQXQXQXQ-UHFFFAOYSA-N }}

5F-MDMB-PICA is a synthetic cannabinoid that has been used as an active ingredient in synthetic cannabis products. It is a potent agonist of the CB1 receptor and has been associated with numerous cases of severe toxicity and fatalities.

Chemical Structure and Properties

5F-MDMB-PICA is chemically classified as an indazole-based synthetic cannabinoid. Its IUPAC name is Methyl 2-[[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino]-3,3-dimethylbutanoate. The compound has a molecular formula of C₂₀H₂₈FN₃O₃ and a molecular weight of 377.46 g/mol.

Pharmacology

5F-MDMB-PICA acts as a potent agonist at the CB1 receptor, which is primarily responsible for the psychoactive effects of cannabinoids. The compound has a high binding affinity for the CB1 receptor, leading to strong psychoactive effects. It has been reported to cause severe adverse effects, including seizures, tachycardia, and acute kidney injury.

Legal Status

5F-MDMB-PICA is classified as a Schedule I controlled substance in the United States, indicating that it is considered to have a high potential for abuse and no accepted medical use. In the United Kingdom, it is classified as a Class B drug under the Misuse of Drugs Act 1971. It is also controlled under various international regulations.

Health Risks

The use of 5F-MDMB-PICA has been associated with numerous health risks. These include severe toxicity, psychosis, and death. The compound has been linked to multiple cases of overdose and has been found in various forensic toxicology reports.

Related Compounds

5F-MDMB-PICA is structurally related to other synthetic cannabinoids such as 5F-ADB, MDMB-CHMICA, and AB-FUBINACA. These compounds share similar pharmacological profiles and have been associated with similar adverse effects.

See Also

• Synthetic cannabinoids
• Cannabinoid receptor
• Forensic toxicology
• Drug overdose