6'-Guanidinonaltrindole

6'-Guanidinonaltrindole (6'-GNTI) is a kappa opioid receptor antagonist used in scientific research. It is derived from the opioid alkaloid Naltrindole.

Chemistry

6'-GNTI is a derivative of the opioid alkaloid Naltrindole. It is a guanidinylated derivative, meaning it has a guanidine group attached to the 6' position of the naltrindole molecule. This modification enhances the selectivity of the compound for the kappa opioid receptor.

Pharmacology

6'-GNTI is a highly selective antagonist for the kappa opioid receptor. It has a high affinity for this receptor and a low affinity for the mu and delta opioid receptors. This selectivity makes it a valuable tool in the study of the kappa opioid system.

Uses in Research

Due to its high selectivity for the kappa opioid receptor, 6'-GNTI is used in scientific research to study the role of this receptor in various physiological and pathological processes. These include pain perception, mood regulation, and the effects of drugs of abuse.

See Also

• Kappa Opioid Receptor
• Naltrindole
• Opioid Receptor

References

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