6,6-Difluoronorethisterone acetate
A synthetic progestogen
6,6-Difluoronorethisterone acetate is a synthetic progestogen that is derived from norethisterone. It is a member of the steroid class of compounds and is used in hormonal contraception and hormone replacement therapy.
Chemical structure and properties[edit | edit source]
6,6-Difluoronorethisterone acetate is a fluorinated steroid with the chemical formula C22H27F2O3. The presence of two fluorine atoms at the 6,6 position of the norethisterone backbone enhances its progestogenic activity and alters its pharmacokinetics.
Mechanism of action[edit | edit source]
As a progestogen, 6,6-Difluoronorethisterone acetate binds to the progesterone receptor in target tissues. This binding leads to changes in gene expression that mimic the effects of endogenous progesterone. These effects include the regulation of the menstrual cycle, maintenance of pregnancy, and modulation of ovulation.
Clinical uses[edit | edit source]
6,6-Difluoronorethisterone acetate is primarily used in contraceptive pills and hormone replacement therapy formulations. Its enhanced stability and activity make it a suitable candidate for these applications, providing effective contraception and alleviating symptoms of menopause.
Pharmacokinetics[edit | edit source]
The pharmacokinetics of 6,6-Difluoronorethisterone acetate involve its absorption, distribution, metabolism, and excretion. The fluorine atoms increase its lipophilicity, allowing for better absorption and distribution in the body. It is metabolized in the liver and excreted primarily through the urinary system.
Side effects[edit | edit source]
Common side effects of 6,6-Difluoronorethisterone acetate include nausea, headache, breast tenderness, and mood changes. Long-term use may be associated with an increased risk of thromboembolic events and breast cancer.
Related pages[edit | edit source]
6,6-Difluoronorethisterone acetate[edit | edit source]
6,6-Difluoronorethisterone acetate structure
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
