60S ribosomal protein L10-like

60S ribosomal protein L10-like is a protein that in humans is encoded by the gene RPL10L. This protein is a component of the ribosome, a complex molecular machine found within all living cells that performs the process of protein synthesis. Ribosomes read the genetic information encoded in messenger RNA (mRNA) and translate it into polypeptide chains. These chains then fold into functional proteins.

Function

The 60S ribosomal protein L10-like is part of the large subunit (60S) of the ribosome. The ribosome consists of two subunits, the small (40S) and large (60S) subunit, each of which contains its own set of proteins and ribosomal RNA (rRNA). The 60S subunit is responsible for the peptidyl transferase activity, which forms peptide bonds between adjacent amino acids using the mRNA as a template. The L10-like protein, similar to its counterpart 60S ribosomal protein L10, plays a critical role in the structure and function of the ribosome, contributing to the fidelity of protein synthesis.

Gene

The gene encoding the 60S ribosomal protein L10-like protein, RPL10L, is located on a specific chromosome. This gene is expressed in various tissues, suggesting a ubiquitous need for its protein product in cellular processes. The regulation of this gene's expression, as well as the processing and modification of its RNA and protein products, are important for the proper assembly and function of ribosomes.

Evolution

The 60S ribosomal protein L10-like and its homologs are highly conserved across different species, indicating their essential role in the ribosome's function. The conservation of these proteins supports the theory that the core components of the ribosome have remained relatively unchanged throughout evolution, reflecting the critical nature of protein synthesis in all forms of life.

Clinical Significance

Alterations in ribosomal proteins, including the 60S ribosomal protein L10-like, can lead to various diseases, known collectively as ribosomopathies. These conditions often result from defects in ribosome biogenesis or function, leading to a wide range of clinical manifestations, including developmental abnormalities and increased susceptibility to certain diseases. Understanding the specific roles of ribosomal proteins like RPL10L can help in the diagnosis and treatment of these conditions.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins
• Ribosomopathy