60S ribosomal protein L39

60S ribosomal protein L39 (RPL39) is a protein that in humans is encoded by the RPL39 gene. This protein is a component of the 60S ribosomal subunit, which is part of the larger ribosome complex responsible for protein synthesis within the cell. Ribosomal proteins play a crucial role in the process of translation, where messenger RNA (mRNA) is decoded to produce specific proteins.

Function

The 60S ribosomal protein L39 is involved in the assembly and function of the 60S subunit of the ribosome. The 60S subunit, together with the 40S ribosomal subunit, forms the complete ribosome. The ribosome performs the vital function of protein biosynthesis, translating mRNA into polypeptide chains. RPL39, like other ribosomal proteins, is essential for the proper functioning of the ribosome, ensuring the accuracy and efficiency of protein synthesis.

Gene

The RPL39 gene is located on chromosome 9 in humans. It encodes the 60S ribosomal protein L39, which is one of the many proteins that constitute the ribosomal 60S subunit. The regulation of ribosomal protein genes, including RPL39, is critical for cell growth and proliferation, as it directly impacts the cell's ability to synthesize proteins.

Clinical Significance

Alterations in the expression of ribosomal proteins, including RPL39, have been associated with various diseases, including cancer. Abnormal levels of ribosomal proteins can disrupt normal cellular function, leading to disease progression. Research into the specific roles of ribosomal proteins like RPL39 in disease states is ongoing, with the aim of developing targeted therapies that can modulate protein synthesis as a means of treatment.

See Also

• Ribosome
• Protein biosynthesis
• Gene expression
• Cell biology