9,11-Dehydrocortexolone 17α-butyrate

9,11-Dehydrocortexolone 17α-butyrate

9,11-Dehydrocortexolone 17α-butyrate is a synthetic glucocorticoid corticosteroid and corticosteroid ester which was never marketed. It is a derivative of hydrocortisone, with an additional double bond between the 9th and 11th carbon atoms and a butyrate ester at the 17α position.

Chemistry

9,11-Dehydrocortexolone 17α-butyrate, also known as 9,11-dehydrocortisol 17α-butyrate, is a synthetic pregnane steroid and a derivative of hydrocortisone (11β,17α,21-trihydroxypregn-4-ene-3,20-dione). It is specifically a derivative of 9,11-dehydrocortisol, or cortexolone, with a double bond between the 9th and 11th carbon atoms and a butyrate ester at the 17α position.

Pharmacology

As a glucocorticoid, 9,11-dehydrocortexolone 17α-butyrate has anti-inflammatory and immunosuppressive effects. It is used in the treatment of various inflammatory and autoimmune conditions. The butyrate ester improves the lipophilicity and hence skin penetration of the drug, making it particularly suitable for topical administration.

See also

• List of glucocorticoids
• List of corticosteroid esters

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