ABCC5

ABCC5 (ATP Binding Cassette Subfamily C Member 5) is a protein that in humans is encoded by the ABCC5 gene. This protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

Function

ABCC5 is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cyclic nucleotides, and folate as substrates. This protein also transports anticancer drugs such as methotrexate and etoposide out of cells, thus contributing to drug resistance in cancer cells.

Clinical significance

Mutations in the ABCC5 gene have been associated with several health conditions. For example, a study found that a specific variant of the ABCC5 gene was associated with a higher risk of chronic kidney disease. Another study found that ABCC5 gene variants were associated with a higher risk of gout.

Structure

The ABCC5 protein is a large protein with 1437 amino acids. It has two homologous halves, each with six transmembrane segments and an ATP binding cassette. The protein is expressed in many tissues, with the highest levels in the kidney and liver.

See also

• ATP-binding cassette transporter
• Multi-drug resistance

External links

• ABCC5 at the National Center for Biotechnology Information