ABL (gene)

ABL (gene)

The ABL gene, also known as ABL1 or c-ABL, is a gene found in humans and other organisms. It is located on chromosome 9 and encodes a protein known as ABL1, which plays a crucial role in various cellular processes, including cell division, adhesion, and stress response cell division, cell adhesion, and stress response.

Function[edit | edit source]

The ABL1 protein is a member of the ABL family of non-receptor tyrosine kinases. It is involved in a variety of cellular processes, including cell growth and division, cell adhesion, and response to oxidative stress. The protein is also involved in the regulation of the cell cycle and apoptosis, and it plays a role in the development and function of the immune system cell cycle, apoptosis, immune system.

Clinical significance[edit | edit source]

Mutations in the ABL gene can lead to a variety of health conditions. The most well-known is chronic myeloid leukemia (CML), a type of cancer that affects the blood and bone marrow. This is caused by a genetic mutation known as the Philadelphia chromosome, which involves a translocation between chromosomes 9 and 22 chronic myeloid leukemia, Philadelphia chromosome.

Other conditions associated with mutations in the ABL gene include acute lymphoblastic leukemia (ALL) and certain types of lung cancer acute lymphoblastic leukemia, lung cancer.

Research[edit | edit source]

Research into the ABL gene and its associated proteins has led to the development of targeted therapies for conditions such as CML. These include tyrosine kinase inhibitors, which block the action of the ABL1 protein and help to control the growth of cancer cells tyrosine kinase inhibitors.