AGPAT9
AGPAT9 is a gene that encodes a protein in humans. This protein is part of the 1-acylglycerol-3-phosphate O-acyltransferase family. This family is known for its role in the lipid metabolism process, specifically in the synthesis of triglycerides and phospholipids.
Function[edit | edit source]
The AGPAT9 gene is responsible for the production of an enzyme known as 1-acylglycerol-3-phosphate O-acyltransferase 9. This enzyme plays a crucial role in the biosynthesis of glycerolipids, a type of fat found in the cell membrane. It does this by converting lysophosphatidic acid (LPA) into phosphatidic acid (PA), a key step in the biosynthesis pathway.
Clinical Significance[edit | edit source]
While the full clinical significance of AGPAT9 is still under investigation, it is believed to play a role in several diseases. For instance, alterations in the AGPAT9 gene have been associated with obesity and insulin resistance. Further research is needed to fully understand the role of AGPAT9 in these and other potential health conditions.
Research[edit | edit source]
Current research is focused on understanding the role of AGPAT9 in lipid metabolism and disease. This includes studying the effects of AGPAT9 mutations on lipid synthesis and how this may contribute to disease development.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
