ARID1A

ARID1A is a gene that encodes a protein involved in chromatin remodeling, a critical process for the regulation of gene expression. The ARID1A protein is a component of the SWI/SNF complex, which is responsible for the rearrangement of chromatin structure. Mutations in the ARID1A gene have been associated with a variety of cancers, including ovarian cancer, endometrial cancer, and gastric cancer.

Function

The ARID1A gene encodes a protein that is part of the SWI/SNF complex. This complex is involved in chromatin remodeling, which is a process that alters the structure of chromatin to allow or prevent the transcription of genes. The ARID1A protein specifically is thought to regulate the binding of the SWI/SNF complex to chromatin.

Clinical significance

Mutations in the ARID1A gene have been implicated in a variety of cancers. These mutations often result in a loss of function of the ARID1A protein, which can lead to unregulated gene expression and the development of cancer.

Ovarian cancer

ARID1A mutations are particularly common in clear cell carcinoma of the ovary and endometrioid carcinoma of the ovary. These mutations are often associated with a poor prognosis.

Endometrial cancer

ARID1A mutations have also been identified in endometrial cancer. These mutations are often associated with a more aggressive form of the disease.

Gastric cancer

In gastric cancer, ARID1A mutations are often associated with a poor prognosis. These mutations are particularly common in gastric adenocarcinoma.

See also

• Chromatin remodeling
• SWI/SNF
• Ovarian cancer
• Endometrial cancer
• Gastric cancer