Acetyldihydrocodeine

Acetyldihydrocodeine is an opioid analgesic that was developed in Germany in 1914. It is related to codeine and is part of the class of drugs known as opioids which also includes morphine, heroin, and oxycodone.

Chemistry

Acetyldihydrocodeine is made by acetylating dihydrocodeine. The acetylation makes the drug more lipid soluble, allowing it to cross the blood-brain barrier more easily, which can increase its potency.

Pharmacology

Like other opioids, acetyldihydrocodeine works by binding to the mu-opioid receptor in the brain and spinal cord. This reduces the perception of pain and produces a feeling of euphoria. It also depresses the respiratory system, which can lead to respiratory failure in overdose.

Medical uses

Acetyldihydrocodeine is used for the relief of moderate to severe pain. It is also used as a cough suppressant, although this use is less common due to the risk of addiction and overdose.

Side effects

Common side effects of acetyldihydrocodeine include drowsiness, nausea, constipation, and dizziness. More serious side effects can include respiratory depression, addiction, and overdose.

Legal status

In many countries, including the United States, acetyldihydrocodeine is a controlled substance, meaning it is illegal to possess without a prescription. It is classified as a Schedule II drug under the Controlled Substances Act in the United States, indicating it has a high potential for abuse and dependence.

See also

• Opioid epidemic
• Opioid overdose
• Opioid use disorder

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