Acral persistent papular mucinosis
A rare skin condition characterized by mucin deposition
Acral persistent papular mucinosis is a rare dermatological condition characterized by the presence of small, firm, skin-colored papules primarily located on the extremities. This condition is a form of mucinosis, where there is an abnormal accumulation of mucin in the skin.
Presentation[edit | edit source]
Acral persistent papular mucinosis typically presents as multiple, small, firm papules that are skin-colored or slightly translucent. These papules are usually found on the hands, feet, and other acral areas, which are the distal parts of the limbs. The papules are persistent and do not tend to resolve spontaneously.
Pathophysiology[edit | edit source]
The underlying cause of acral persistent papular mucinosis is the excessive deposition of mucin in the dermis. Mucin is a glycoprotein that is normally present in the skin, but in this condition, it accumulates in higher than normal amounts. The exact mechanism leading to this accumulation is not well understood, but it is thought to be related to an abnormality in the fibroblasts that produce mucin.
Diagnosis[edit | edit source]
The diagnosis of acral persistent papular mucinosis is primarily clinical, based on the characteristic appearance and distribution of the papules. A skin biopsy can be performed to confirm the diagnosis, which will show mucin deposition in the dermis upon histological examination. Special stains, such as Alcian blue, can be used to highlight the presence of mucin.
Treatment[edit | edit source]
There is no specific treatment for acral persistent papular mucinosis, and management is usually focused on symptomatic relief. In some cases, topical or intralesional corticosteroids may be used to reduce inflammation and improve the appearance of the papules. However, the condition is generally benign and does not require aggressive treatment.
Prognosis[edit | edit source]
Acral persistent papular mucinosis is a benign condition with a chronic course. The papules tend to persist over time but do not usually lead to any significant complications. The condition does not have any known association with systemic diseases.
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Contributors: Prab R. Tumpati, MD
