Adult T-cell leukemia/lymphoma
(Redirected from Adult T-cell leukemia)
Alternate names[edit | edit source]
ATLL; Adult T-cell leukaemia; Adult T-cell leukaemia/lymphoma (HTLV-1 positive); Adult T-cell lymphoma
Definition[edit | edit source]
(uh-DULT T-sel loo-KEE-mee-uh/lim-FOH-muh)An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma caused by the human T-cell leukemia virus type 1 (HTLV-1). It is marked by bone and skin lesions, high calcium levels, and enlarged lymph nodes, spleen, and liver. Also called ATLL.
Epidemiology[edit | edit source]
- ATLL and HTLV‐I are prevalent in Japan, the Caribbean basin, and certain regions of South America and Africa, and in immigrants from these countries to other regions. [1].
- It has also been recognised in patients originating from Iran and Central Europe.
- In the UK, ATLL is mainly, but not exclusively, seen in first or second generation immigrants of Afro‐Caribbean descent.
Cause[edit | edit source]
- It is aetiologically linked to the human T‐cell lymphotropic virus, HTLV‐I.
- HTLV‐I is detected in cells from virtually all cases of ATLL, with exceedingly rare exceptions.
Types[edit | edit source]
There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases).
Signs and symptoms[edit | edit source]
- The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as “holes” on a standard bone x-ray), and skin lesions.
Diagnosis[edit | edit source]
- The diagnosis should be based on a constellation of clinical features and laboratory investigations. [2].
- The latter comprise: lymphocyte morphology, immunophenotype, histology of the tissues affected in the pure lymphoma forms and serology or DNA analysis for HTLV‐I.
Treatment[edit | edit source]
- The best treatment for these patients is unclear and patients should be enrolled in clinical trials whenever possible.
- Medication may include CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone) or EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone).
- In some patients, a bone marrow transplant may be recommended.[3].
References[edit | edit source]
- ↑ Matutes E. (2007). Adult T-cell leukaemia/lymphoma. Journal of clinical pathology, 60(12), 1373–1377. https://doi.org/10.1136/jcp.2007.052456
- ↑ Matutes E. (2007). Adult T-cell leukaemia/lymphoma. Journal of clinical pathology, 60(12), 1373–1377. https://doi.org/10.1136/jcp.2007.052456
- ↑ Matutes E. (2007). Adult T-cell leukaemia/lymphoma. Journal of clinical pathology, 60(12), 1373–1377. https://doi.org/10.1136/jcp.2007.052456
NIH genetic and rare disease info[edit source]
Adult T-cell leukemia/lymphoma is a rare disease.
| Adult T-cell leukemia/lymphoma Resources | |
|---|---|
|
 |
| Adult T-cell leukemia/lymphoma Resources | |
|---|---|
|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Deepika vegiraju
