Ae binding protein 1

Ae binding protein 1 (AEBP1) is a protein that in humans is encoded by the AEBP1 gene. This protein plays a crucial role in adipogenesis, the process by which fat cells differentiate from predesessor cells.

Function

AEBP1 is a transcriptional repressor with carboxypeptidase (CP) activity; it is expressed in adipose tissue. The encoded protein binds to a specific sequence in the promoter of target genes, leading to their repression in cells. The protein has been shown to interact with CCAAT/enhancer-binding proteins, thereby halting the transcriptional activity of the latter.

Clinical significance

Alterations in the AEBP1 gene have been associated with a variety of health conditions. For instance, mutations in this gene have been linked to autosomal recessive forms of lymphedema, a condition characterized by swelling in the arms and legs due to a blockage in the lymphatic system.

Furthermore, overexpression of AEBP1 has been observed in various types of cancer, including breast cancer and colorectal cancer. This overexpression is thought to contribute to cancer progression by promoting cell proliferation and angiogenesis, the formation of new blood vessels.

Research

Research into AEBP1 is ongoing, with scientists seeking to better understand its role in health and disease. For example, studies are investigating the protein's role in obesity and metabolic syndrome, given its involvement in adipogenesis.

The structure of the AEBP1 protein. Image from Wikimedia Commons.

See also

• Adipogenesis
• Transcription (genetics)
• CCAAT/enhancer-binding proteins
• Lymphedema
• Breast cancer
• Colorectal cancer