Aildenafil
Aildenafil is a phosphodiesterase type 5 inhibitor used for erectile dysfunction.
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Aildenafil is a phosphodiesterase type 5 inhibitor (PDE5 inhibitor) used primarily in the treatment of erectile dysfunction. It is chemically related to sildenafil, the active ingredient in Viagra.
Mechanism of Action[edit | edit source]
Aildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is found in various tissues of the body, including the corpus cavernosum of the penis. By inhibiting PDE5, aildenafil increases the levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation and increased blood flow to the penis, facilitating an erection in response to sexual stimulation.
Pharmacokinetics[edit | edit source]
Aildenafil is absorbed rapidly after oral administration. The onset of action is typically within 30 to 60 minutes, and the duration of effect can last up to 4 hours. The drug is metabolized primarily in the liver by the cytochrome P450 enzyme system, particularly CYP3A4.
Side Effects[edit | edit source]
Common side effects of aildenafil include headache, flushing, dyspepsia, and nasal congestion. Less common side effects may include dizziness, visual disturbances, and priapism. Patients are advised to seek immediate medical attention if an erection lasts longer than 4 hours.
Contraindications[edit | edit source]
Aildenafil is contraindicated in patients taking nitrates for angina or other heart conditions, as the combination can lead to a dangerous drop in blood pressure. It is also contraindicated in patients with severe cardiovascular disease, liver impairment, or retinitis pigmentosa.
Interactions[edit | edit source]
Aildenafil can interact with other medications, including alpha-blockers, antihypertensives, and CYP3A4 inhibitors. These interactions can affect the efficacy and safety of aildenafil, and dose adjustments may be necessary.
Related pages[edit | edit source]
Aildenafil
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