Alestramustine
| Alestramustine | |
|---|---|
| |
| INN | |
| Drug class | Chemotherapeutic agent; Estrogen; Estrogen ester |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | 139402-18-9 |
| PubChem | 20055302 |
| DrugBank | |
| ChemSpider | 16736564 |
| KEGG | |
Alestramustine (INN
), also known as estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(L-alaninate), is a cytostatic antineoplastic agent which was never marketed.[1][2] It is the L-alanine ester of estramustine, which is a combination of the nitrogen mustard normustine coupled via a carbamate to the estrogen estradiol.[1][3] Alestramustine acts as a prodrug to estramustine, and also forms estradiol as a byproduct.[1][3] The drug, via its active metabolites, binds to microtubule-associated proteins and β-tubulin and interferes with microtubule function, thereby inhibiting cell division.[1][3] Due to its estrogen moiety, alestramustine is selectively concentrated in estrogen receptor-positive cells such as prostate and breast.[1]
See also[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 1.2 1.3 1.4 Alestramustine Full text, NCI Thesaurus, ,
- ↑ {{{last}}}, G. W. A. Milne, Ashgate Handbook of Antineoplastic Agents. online version, Wiley, ISBN 978-0-566-08382-2,
- ↑ 3.0 3.1 3.2 {{{last}}}, KD Tripathi, Essentials of Medical Pharmacology. online version, JP Medical Ltd, ISBN 978-93-5025-937-5, Pages: 866–,
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