Alkb homolog 3, alpha-ketoglutaratedependent dioxygenase

Alkb homolog 3, alpha-ketoglutaratedependent dioxygenase (ALKBH3) is an enzyme that in humans is encoded by the ALKBH3 gene. This enzyme belongs to the AlkB family and is involved in the direct reversal of DNA alkylation damage.

Function

ALKBH3 is a member of the AlkB family of proteins, which are involved in the repair of alkylation damage in DNA and RNA. The enzyme uses alpha-ketoglutarate and oxygen to remove alkyl groups from DNA, a process known as oxidative demethylation. This process is crucial for maintaining the integrity of the genetic code and preventing mutations that can lead to diseases such as cancer.

Structure

The ALKBH3 protein is composed of 389 amino acids and has a molecular weight of approximately 43 kDa. It contains a conserved AlkB domain, which is responsible for its catalytic activity. The structure of the protein also includes a zinc finger domain, which is thought to be involved in DNA binding.

Clinical significance

Mutations in the ALKBH3 gene have been associated with an increased risk of certain types of cancer, including prostate cancer and lung cancer. The enzyme is overexpressed in these cancers, suggesting that it may play a role in their development or progression.

See also

• AlkB homolog
• DNA repair
• Alpha-ketoglutarate