Alkb homolog 3, alpha-ketoglutaratedependent dioxygenase
From WikiMD's Wellness Encyclopedia
Alkb homolog 3, alpha-ketoglutaratedependent dioxygenase (ALKBH3) is an enzyme that in humans is encoded by the ALKBH3 gene. This enzyme belongs to the AlkB family and is involved in the direct reversal of DNA alkylation damage.
Function[edit | edit source]
ALKBH3 is a member of the AlkB family of proteins, which are involved in the repair of alkylation damage in DNA and RNA. The enzyme uses alpha-ketoglutarate and oxygen to remove alkyl groups from DNA, a process known as oxidative demethylation. This process is crucial for maintaining the integrity of the genetic code and preventing mutations that can lead to diseases such as cancer.
Structure[edit | edit source]
The ALKBH3 protein is composed of 389 amino acids and has a molecular weight of approximately 43 kDa. It contains a conserved AlkB domain, which is responsible for its catalytic activity. The structure of the protein also includes a zinc finger domain, which is thought to be involved in DNA binding.
Clinical significance[edit | edit source]
Mutations in the ALKBH3 gene have been associated with an increased risk of certain types of cancer, including prostate cancer and lung cancer. The enzyme is overexpressed in these cancers, suggesting that it may play a role in their development or progression.
See also[edit | edit source]
References[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian