Alpha 1 antitrypsin deficiency

Alpha 1 antitrypsin deficiency - a genetic disorder characterized by decreased alpha 1 antitrypsin activity in the lungs and blood and deposition of alpha 1 antitrypsin protein in the hepatocytes. These abnormalities result from defective production of alpha 1 antitrypsin and lead to the development of emphysema, cirrhosis, and liver failure.

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