Aminopeptidase A inhibitor

Aminopeptidase A inhibitor is a type of enzyme inhibitor that specifically targets aminopeptidase A, an enzyme involved in the regulation of blood pressure and fluid balance in the body. These inhibitors have potential therapeutic applications in the treatment of hypertension and other cardiovascular diseases.

Mechanism of Action

Aminopeptidase A is responsible for the conversion of angiotensin II to angiotensin III, which is a potent vasoconstrictor. By inhibiting aminopeptidase A, these inhibitors reduce the production of angiotensin III, thereby decreasing vasoconstriction and lowering blood pressure.

Therapeutic Applications

Aminopeptidase A inhibitors are currently being investigated for their potential use in the treatment of hypertension, heart failure, and kidney disease. They may also have potential applications in the treatment of anxiety disorders, as aminopeptidase A is involved in the regulation of the stress response.

Side Effects

As with all medications, aminopeptidase A inhibitors may have potential side effects. These can include nausea, dizziness, and headache. However, these side effects are generally mild and manageable.

Research and Development

Several aminopeptidase A inhibitors are currently in the research and development stage. These include ecallantide, a recombinant protein that inhibits aminopeptidase A, and firazyr, a synthetic peptide that also inhibits this enzyme.

See Also

• Enzyme inhibitor
• Aminopeptidase
• Hypertension
• Cardiovascular disease