Aminophenazone

Aminophenazone (or amidopyrine) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties. It was introduced in the late 19th century and was widely used in the mid-20th century for a variety of conditions, including headache, toothache, menstrual pain, and fever. However, it has been largely withdrawn from the market due to the risk of agranulocytosis.

History

Aminophenazone was first synthesized by the German company Hoechst AG in 1893. It was widely used in the mid-20th century for a variety of conditions, but has since been largely withdrawn from the market due to the risk of agranulocytosis.

Medical uses

Aminophenazone has analgesic, anti-inflammatory, and antipyretic properties, making it useful for the relief of pain and the reduction of fever. It was commonly used for the treatment of headache, toothache, menstrual pain, and fever.

Side effects

The most serious side effect of aminophenazone is agranulocytosis, a severe and potentially fatal condition in which the body's white blood cells are drastically reduced, leading to a weakened immune system. Other side effects may include allergic reactions, nausea, and vomiting.

Mechanism of action

Aminophenazone is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, chemicals in the body that cause inflammation and pain.

Legal status

Due to the risk of agranulocytosis, aminophenazone has been withdrawn from the market in many countries. However, it is still available in some countries, often in combination with other drugs.

See also

• Analgesic
• Antipyretic
• Nonsteroidal anti-inflammatory drug
• Agranulocytosis

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