Aminophenazone
Aminophenazone[edit | edit source]
2D Skeletal Structure of Aminophenazone
3D Ball-and-Stick Model of Aminophenazone
Aminophenazone[edit | edit source]
Aminophenazone, also known as aminopyrine, is a non-opioid analgesic and antipyretic drug that was widely used in the past for its pain-relieving and fever-reducing properties. It belongs to the class of pyrazolone derivatives and was first introduced in the early 20th century.
Chemical Structure and Properties[edit | edit source]
Aminophenazone is a derivative of phenazone, with the chemical formula C13H17N3O. It is characterized by the presence of an amino group attached to the pyrazolone ring. The compound is a white crystalline powder that is soluble in water and alcohol.
Pharmacology[edit | edit source]
Aminophenazone works by inhibiting the synthesis of prostaglandins, which are compounds involved in the mediation of pain and inflammation. It exerts its effects primarily through the inhibition of the cyclooxygenase (COX) enzymes, similar to other non-steroidal anti-inflammatory drugs (NSAIDs).
Medical Uses[edit | edit source]
Historically, aminophenazone was used to treat a variety of conditions, including:
However, due to safety concerns, its use has been largely discontinued in many countries.
Safety and Side Effects[edit | edit source]
Aminophenazone has been associated with several adverse effects, the most significant being agranulocytosis, a potentially life-threatening condition characterized by a severe reduction in the number of white blood cells. This risk led to the withdrawal of aminophenazone from the market in many regions.
Other side effects may include:
Regulatory Status[edit | edit source]
Due to the risk of agranulocytosis and other side effects, aminophenazone is no longer widely used and has been replaced by safer alternatives such as paracetamol and ibuprofen. In some countries, its use is restricted to specific cases under medical supervision.
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