Amlodipine besylate

Amlodipine besylate is a medication used primarily in the treatment of high blood pressure and angina. It is a type of drug known as a calcium channel blocker, which works by relaxing the blood vessels, allowing blood to flow more easily, and reducing the heart's workload.

Pharmacology

Amlodipine besylate inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle. It achieves this by binding to dihydropyridine and non-dihydropyridine binding sites. The overall effect is a decrease in vascular resistance and blood pressure.

Clinical Use

Amlodipine besylate is used to treat hypertension, chronic stable angina, and confirmed or suspected vasospastic angina. It can be used alone or in combination with other antihypertensive agents.

Side Effects

Common side effects of amlodipine besylate include edema, fatigue, palpitations, and dizziness. More serious side effects can include hypotension, bradycardia, and hepatotoxicity.

Contraindications

Amlodipine besylate is contraindicated in patients with known sensitivity to dihydropyridine derivatives, amlodipine, or any of the excipients in the formulation.

Interactions

Amlodipine besylate can interact with a number of other medications, including simvastatin, warfarin, and cimetidine. It is important for patients to inform their healthcare provider of all medications they are currently taking.

Dosage

The usual initial antihypertensive oral dose of amlodipine besylate for adults is 5 mg once daily, with a maximum dose of 10 mg once daily. Doses should be adjusted according to each individual's response.

See Also

• Calcium channel blocker
• Hypertension
• Angina