Amlodipine besylate

Amlodipine besylate is a medication used primarily in the treatment of high blood pressure and angina. It is a type of drug known as a calcium channel blocker, which works by relaxing the blood vessels, allowing blood to flow more easily, and reducing the heart's workload.

Pharmacology[edit | edit source]

Amlodipine besylate inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle. It achieves this by binding to dihydropyridine and non-dihydropyridine binding sites. The overall effect is a decrease in vascular resistance and blood pressure.

Clinical Use[edit | edit source]

Amlodipine besylate is used to treat hypertension, chronic stable angina, and confirmed or suspected vasospastic angina. It can be used alone or in combination with other antihypertensive agents.

Side Effects[edit | edit source]

Common side effects of amlodipine besylate include edema, fatigue, palpitations, and dizziness. More serious side effects can include hypotension, bradycardia, and hepatotoxicity.

Contraindications[edit | edit source]

Amlodipine besylate is contraindicated in patients with known sensitivity to dihydropyridine derivatives, amlodipine, or any of the excipients in the formulation.

Interactions[edit | edit source]

Amlodipine besylate can interact with a number of other medications, including simvastatin, warfarin, and cimetidine. It is important for patients to inform their healthcare provider of all medications they are currently taking.

Dosage[edit | edit source]

The usual initial antihypertensive oral dose of amlodipine besylate for adults is 5 mg once daily, with a maximum dose of 10 mg once daily. Doses should be adjusted according to each individual's response.