Anion exchange protein 2

Anion exchange protein 2 (also known as AE2) is a protein that in humans is encoded by the SLC4A2 gene. It is a member of the solute carrier family of proteins, specifically the anion exchanger subfamily. This protein is primarily found in the cell membrane and functions to remove chloride ions from cells while bringing in bicarbonate ions.

Function

The primary function of the anion exchange protein 2 is to facilitate the exchange of chloride ions for bicarbonate ions across the cell membrane. This process is crucial for the regulation of pH within the cell and the body. The protein also plays a role in the formation of stomach acid, and mutations in the SLC4A2 gene can lead to conditions such as distal renal tubular acidosis.

Structure

Anion exchange protein 2 is a transmembrane protein, meaning it spans the entire width of the cell membrane. It is composed of multiple domains, including a transmembrane domain and a cytoplasmic domain. The transmembrane domain is responsible for the actual exchange of ions, while the cytoplasmic domain is involved in regulating the activity of the protein.

Clinical significance

Mutations in the SLC4A2 gene can lead to a variety of health conditions. For example, a mutation that results in a nonfunctional anion exchange protein 2 can lead to distal renal tubular acidosis, a condition characterized by a failure of the kidneys to properly remove acids from the blood. Other conditions associated with mutations in the SLC4A2 gene include gallstones and osteopetrosis.

See also

• Anion exchanger 1
• Anion exchanger 3
• Solute carrier family

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian