Anion exchange protein 2
Anion exchange protein 2 (also known as AE2) is a protein that in humans is encoded by the SLC4A2 gene. It is a member of the solute carrier family of proteins, specifically the anion exchanger subfamily. This protein is primarily found in the cell membrane and functions to remove chloride ions from cells while bringing in bicarbonate ions.
Function[edit | edit source]
The primary function of the anion exchange protein 2 is to facilitate the exchange of chloride ions for bicarbonate ions across the cell membrane. This process is crucial for the regulation of pH within the cell and the body. The protein also plays a role in the formation of stomach acid, and mutations in the SLC4A2 gene can lead to conditions such as distal renal tubular acidosis.
Structure[edit | edit source]
Anion exchange protein 2 is a transmembrane protein, meaning it spans the entire width of the cell membrane. It is composed of multiple domains, including a transmembrane domain and a cytoplasmic domain. The transmembrane domain is responsible for the actual exchange of ions, while the cytoplasmic domain is involved in regulating the activity of the protein.
Clinical significance[edit | edit source]
Mutations in the SLC4A2 gene can lead to a variety of health conditions. For example, a mutation that results in a nonfunctional anion exchange protein 2 can lead to distal renal tubular acidosis, a condition characterized by a failure of the kidneys to properly remove acids from the blood. Other conditions associated with mutations in the SLC4A2 gene include gallstones and osteopetrosis.
See also[edit | edit source]
References[edit | edit source]
Transform your life with W8MD's budget GLP1 injections in NYC from $125 and up biweekly
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Contrave, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD