Antiangiogenesis

Antiangiogenesis is a medical term that refers to the inhibition of angiogenesis, the physiological process through which new blood vessels form from pre-existing vessels. This process is fundamental in growth and development, as well as in wound healing and the formation of granulation tissue. However, it is also a critical component in the growth of cancer as it allows tumors to grow beyond a certain size by ensuring they have a sufficient blood supply.

Mechanism of Action

Antiangiogenesis works by blocking the signals that stimulate the growth of new blood vessels. The body naturally controls angiogenesis by producing a precise balance of growth and inhibitory factors in healthy tissues. When this balance is disturbed, the result is either too much or too little angiogenesis. Antiangiogenic agents work to restore this balance, preventing the growth of new blood vessels and starving the tumor of its blood supply.

Antiangiogenic Therapy

Antiangiogenic therapy is a form of targeted therapy used in the treatment of cancer. It is designed to prevent the growth of new blood vessels, thereby starving the tumor of the nutrients it needs to grow. This form of therapy has been shown to be effective in the treatment of various types of cancer, including breast cancer, lung cancer, colorectal cancer, and glioblastoma.

Drugs

Several drugs have been developed that have antiangiogenic properties. These include bevacizumab (Avastin), sunitinib (Sutent), and sorafenib (Nexavar). These drugs work by inhibiting the vascular endothelial growth factor (VEGF), a key driver of angiogenesis.

Side Effects

Like all therapies, antiangiogenic therapy can have side effects. These can include high blood pressure, fatigue, and a risk of bleeding. However, these side effects are generally manageable and the benefits of the therapy often outweigh the risks.

Future Research

Research into antiangiogenesis is ongoing, with scientists continually seeking to understand more about how this process works and how it can be manipulated to treat cancer. Future developments may include the discovery of new antiangiogenic agents, as well as the development of combination therapies that use antiangiogenic drugs alongside other treatments.