Mitotic inhibitor

Mitotic inhibitors are a type of cancer treatment that prevent cancer cells from dividing and multiplying. They are a class of drugs that target the mitosis (cell division) process in the cell cycle, disrupting the division and growth of cancer cells.

Mechanism of Action

Mitotic inhibitors work by disrupting the microtubules in the cell's structure. Microtubules are essential for cell division, and by preventing their formation, mitotic inhibitors can stop the cell from dividing. This is particularly effective against cancer cells, which divide and multiply at a much faster rate than normal cells.

Types of Mitotic Inhibitors

There are several types of mitotic inhibitors, including taxanes and vinca alkaloids. Taxanes, such as paclitaxel and docetaxel, work by stabilizing the microtubules and preventing them from disassembling, which is necessary for cell division. Vinca alkaloids, such as vincristine and vinblastine, work by preventing the formation of microtubules, thus inhibiting cell division.

Uses

Mitotic inhibitors are used in the treatment of various types of cancer, including breast cancer, lung cancer, ovarian cancer, and lymphoma. They are often used in combination with other types of cancer treatments, such as radiation therapy and chemotherapy.

Side Effects

Like all cancer treatments, mitotic inhibitors can have side effects. These can include nausea, vomiting, hair loss, and neuropathy. It is important for patients to discuss these potential side effects with their healthcare provider before starting treatment.

See Also

• Chemotherapy
• Cancer treatment
• Cell cycle
• Microtubule